Biofilm is an enemy worth targeting

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生物膜(Biofilm)可被定義為，微生物細胞附著於活體或非活體的表面，藉由自體分泌出的黏液形成一個細胞外聚合物(EPS)的保護層。生物膜能抵抗抗生素和抗菌劑，導致持續不斷的發炎與感染。1,2

 

生物膜是一個非常大的問題：

  • 它存在在至少78%的慢性傷口上3
  • 它難以被根除
  • 它會延遲傷口癒合4,5
biofilm enemy (Mandarin for website content)

 

LEARN MORE ABOUT :

1. Gurjala AN et al. Development of a novel, highly quantitative in-vivo model for the study of biofilm-impaired cutaneous wound healing. Wound Rep Reg (2011) 19 400-410.
2. Hall-Stoodley LI et al. Towards diagnostic guidelines for biofilm-associated infections. FEMS Immunol Med Microbiol. 2012; 65:127-145.
3. Malone M et al. 2017. The prevalence of biofilm in chronic wounds: a systematic review and meta-analysis of published data. JWC; 20-25.
4. Hurlow, J., Couch, K., Laforet, K., Bolton, L., Metcalf, D. et al. (2015). Clinical Biofilms: A Challenging Frontier in Wound Care. Advances in Wound Care, 4(5). 295-301.
5. Metcalf, Bowler. Biofilm delays would healing: a review of the evidence. Burns Trauma 2013; 1: 5-12.
6. Wolcott RD et al. Biofilm maturity studies indicate sharp debridement opens a time dependent therapeutic window. J Wound Care. 2010; 19: 320-328.
7. Costerton JW, Stewart PS, Greenberg EP. Bacterial Biofilms: A Common Cause of Persistent Infections. 1999: 284 Science.

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